CBD a.k.a. Cannabidiol: A closer look

TABLE OF CONTENTS:

Cannabidiol is a Phyto-cannabinoid derived from the Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemo preventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1.

CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1.

Source: https://pubchem.ncbi.nlm.nih.gov/compound-cannabidiol


WHAT DOES ALL THIS MEAN?

CBD is a non-psychoactive (no high) component of the Cannabis plant, with anti-inflammatory and pain relieving properties. It also has components that stunt tumor growth and potentially prohibit cancer cells from continuing to form or spread. It’s main use is for anti-anxiety or anxiolytic medicines. Studies have found it can be used for a variety of purposes, from post workout recovery to calming prior to bedtime, supporting a restful nights sleep. CBD is great for social situations for the anxious, anyone looking for immediate relief without the high. It is 100% legal in the United States.

To reiterate, it will NOT get you high.


FULL SPECTRUM CBD vs. CBD ISOLATE

“It was previously believed that CBD in its isolated form was more potent and concentrated than full spectrum CBD; however, in 2015, the theory was debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the study, researchers administered full spectrum CBD and CBD isolate to two different groups of mice. When comparing the data of the two groups, the results proved that the group administered with full spectrum CBD were provided with higher levels of relief. Furthermore, the study demonstrated that full spectrum CBD continued to provide relief as the dose increased, while CBD Isolate did not provide the same effect when there was an increase in dosage. While full spectrum CBD has ultimately proven to be more effective than CBD Isolate and can be used to effectively treat a wide variety of ailments, it does not discredit the effectiveness of CBD Isolate. There are a wide variety of situations when CBD Isolate would be preferred over Full Spectrum CBD. For example, you may not necessarily need the full capabilities of Full Spectrum CBD, or if you aren’t legally allowed to use THC. It is also important to note that other cannabinoids may cause negative reactions when isolated CBD wouldn’t (if the condition you are suffering from is critical, we definitely advise you speak to a medical consultant before trying out any version of CBD).”

Source: https://medium.com/cbd-origin/cbd-isolate-vs-full-spectrum-cbd

Full spectrum CBD vs. Pure CBD Isolate is a highly debated topic of research for many people. When making your decision, you want to truly understand why to pick one over the other.

When purchasing CBD products, you have multiple options:

  • Full Spectrum CBD (Trace amounts of THC)
  • Broad Spectrum CBD (Usually the term used when THC has been removed from Full Spectrum CBD)
  • CBD Isolate (Zero THC)

There’s a tendency for a lengthy debate on one being better than the other, as if it’s some sort a riddle, but that would take years of advanced scientific study to figure out. Though, it’s not that difficult. The choice simply comes down to your own personal preferences. When you understand the difference between Full Spectrum CBD and CBD Isolate, you will be able to choose the product that best suits your own needs.

While there is no debate that CBD offers the most benefits compared to any single cannabinoid, many wonders if CBD Isolate alone is more effective for treating ailments than Full Spectrum CBD, where all the cannabinoids are combined or vice versa. There are a few key differences you’ll want to be aware of. Allow us to break it down...


Full Spectrum CBD

For a more holistic approach to using CBD – a Full Spectrum CBD product may be your best bet. There is a tipping scale so to speak, one being precision and the other being all inclusive, or precise.

Full Spectrum CBD refers to pure hemp oil that features all the same cannabinoids present in the original hemp plant. In other words, everything is used, nothing gets left behind. This all-natural CBD oil concentrate allows the cannabinoids and terpenes to work together in what is called the “entourage effect.” Different cannabinoids introduce various potential benefits that can address a wide variety of ailments, both on their own and in conjunction with one another.

Full Spectrum CBD oil also contains minimal amounts of THC, since nothing is removed from the cannabis plant. However, this amount will not generally cause psychoactive effects.

While some suggest that Full Spectrum CBD may be more effective than CBD Isolate, even at lower dosages, it may have some drawbacks.

  • Your state may not legally allow the use of THC
  • Other cannabinoids presented in Full Spectrum CBD may cause negative allergic reactions for humans and pets. CBD Isolate will not.
  • Full Spectrum CBD is not suggested for those who may be subject to drug testing, where completely avoiding THC is obviously important

So, if there are reasons you should avoid Full Spectrum CBD oil, that does not mean that you need to avoid CBD usage completely. CBD Broad Spectrum and CBD Isolate products are an excellent choice.

IMPORTANT NOTE: With Full Spectrum CBD products, you usually get smaller concentrations of CBD

For example: If a company uses a product that only offers 10% - 38% CBD, you may be getting 15mg/ml with only 10% CBD Concentration. Let’s break it down...

10% CBD Concentration is one of the rawest forms of CBD hemp oil, that is extracted from the plant using a solvent-free CO² extraction process. There is no heating involved, which maintains most of all the plant’s natural constituents like chlorophyll and CBDa (cannabidiolic acid).

Bottom line is about 10% CBD

17% CBD Concentration takes the extracted hemp oil from above and decarboxylates (heats) it, which results in the CBDa turning into CBD, creating a higher concentration of the compound.

Bottom line is about 17% CBD

24% CBD Concentration takes the above a step further with a signature filtration process, removing most of the plant material and improving its consistency and taste.

Bottom line is about 24% CBD

38% CBD Concentration is a mixture of the oils above. This one is debatable because there aren’t enough studies on it yet and test results can widely vary.

Bottom line is about 26-38% CBD
Our Latest Lab Results


CBD ISOLATE:

Isolating the perceived valuable aspects of any substance is a common approach in the pharmaceutical model. This is because it works to maximize an ‘active ingredient’ to its utmost efficacy and safety. Put simply, CBD Isolate is CBD in its purest form, separated (isolated) from all other cannabis materials and chemicals that are present alongside CBD in the cannabis plant. However, CBD does contain most of the benefits of all the other cannabinoids in cannabis combined.


Benefits of CBD:
  • antibacterial
  • inhibits cancer cell growth (CBDA, CBG, CBC, A9-THCA)
  • Neuro-protective
  • promotes bone growth (CBG, CBC, THCV)
  • reduces risk of artery blockage
  • reduces seizures and convulsions (THCV)
  • increases function in the immune system
  • reduces inflammation (CBDA, CBGA, CBC, CBCA)
  • reduces nausea and vomiting (A9-THC)
  • relieves pain (CBGA, CBC, A9-THC, A8-THC)
  • relieves anxiety
  • slows bacteria growth (CBG, CBGA)
  • suppresses muscle spasms (A9-THCA, A9-THC)
  • tranquilizing
  • reduces blood sugar levels
  • treats psoriasis
  • reduces small intestine contractions
  • vasorelaxant
  • helps Crohn’s disease
  • aides with shaking from Parkinson’s

Our CBD Isolate at Zen Alchemy Labs is first extracted from non-GMO, pesticide free, organically grown Hemp in Oregon using CO2 extraction, which leads to the extraction of resins and oils from hemp. The CBD hemp oil is then purified to filter plant material and remove excess waxes. CBD is isolated by cooling extracted oil until it forms into crystals. These crystals are crushed into a fine powder. What remains after this is pure CBD isolate. This process produces a nearly-pure CBD Isolate powder but removes the additional cannabinoids, terpenes, and other compounds that Full Spectrum hemp oil contains, including any traces of THC.

Benefits include:
  • Users can specify exactly how much CBD they are using. This is because it is over 99% pure, so precision and dosage are easy to note.
  • Usually tasteless and odorless.
  • Effective on its own.
  • Preferred by those maximizing their CBD intake.
  • Preferred for those looking to avoid THC. For example, athletes or employees who may be drug-tested.
  • Incredibly versatile for those who need CBD’s medicinal properties at work or out in public.


BROAD SPECTRUM CBD

Broad Spectrum CBD is a little bit of both. Broad-spectrum CBD is Full Spectrum CBD without THC. It offers all the entourage benefits associated with Full Spectrum CBD, without any chances of THC being ingested into the body. However, just like Full Spectrum CBD, other cannabinoids presented in Broad Spectrum CBD may cause negative allergic reactions for humans and pets, where CBD Isolate will not. If Full Spectrum or Broad-Spectrum CBD is not an option for you due to your employment, obligations or personal preferences, this can help make the decision easier. Knowing at any given moment, you have the option to receive immediate medicinal healing benefits without negative repercussions. The only way to discover which source of CBD is right for you is to give it a try, evaluate and go from there. If you don’t like one CBD product, you can always switch to another. That’s the beauty of cannabis: there’s no right or wrong way to use it. Whatever works best for you; you can pick and choose as you see fit.

Source: https://www.cbdschool.com/what-is-broad-spectrum-cbd


INGESTING vs. VAPING

There’s more than one way to peel an orange, and this couldn’t be truer when it comes to CBD. Though on this note, topically administering CBD still has much more research to prove its viability. With the rising demands for CBD, the method of intake has become very diverse. From sprays, vaping, tinctures, and even just smoking a good old-fashioned joint.

What most people aren’t aware of is the way in which you are intaking it, can alter the effective dosage immensely. There is a term called bioavailability, meaning not all of the CBD that you intake will directly affect your body. Only a percentage will enter your bloodstream. Oral bioavailability ranges anywhere between 10-20%, depending on the person. So, for every 100mg of CBD you ingest, your body would potentially receive 10-20mg of its benefits.

CBD is hydrophobic, meaning it doesn’t dissolve in water well, like cinnamon in this regard. Because of this, CBD does not like to remain in your bloodstream, it rapidly diffuses out of your blood and accumulates into fatty cells. Because of this, less CBD can be carried to the active sites on the body and lowering its bioavailability as a result. This can take up to 30-60 minutes for your body to feel its effects. Second, when you ingest it, it must pass through the liver before it can enter the bloodstream. During this time, the liver will absorb a large portion of the CBD and discard the rest. It does this through absorption or via enzymes. This is called the “first-pass effect” in medical journals and happens to any bioactive compound that enters the liver.

So, how do we get around this? Well, for starters we must make the CBD more hydrophilic, and we do this by dissolving it into a vape liquid. This is a more practical solution as it skips the liver and the “first-pass effect” entirely, and increases the amount of CBD that can pass through the bloodstream. During vaporization, CBD enters your lungs then directly to your bloodstream, skipping your stomach and liver entirely. This increases the bioavailability of CBD by almost 60%, achieving higher quality results, at a much lower dosage. At this point, you could achieve approximately 75% CBD absorption, versus 10-15% from ingestion. Vaping CBD is ideal for immediate relief, providing vast healing benefits in under 5 minutes.

Very few companies can produce a homogenous CBD solution, Zen Alchemy Labs guarantees each ml of solution contains between 95-105mg of CBD Isolate. Each pod sits happily around 100mg with a 1% differential during production.

In a nutshell, source your desired CBD from a trustworthy provider. From oil capsules to tinctures, edibles, vaping, and other CBD products, read the label, do the research, confirm their lab test results and invest in high quality. You don’t want to cut corners when it comes to things you invest in and put in your body.


Propylene Glycol (PG) & Vegetable Glycerin (VG)

These are both very commonly used transmitters for vaping, with high popularity in the vape community for over 20 years. Yes, vaping has been around a lot longer than most people are aware of. In the new up and coming CBD community there has been biased saying they act as fillers, are unsafe, unnatural, or not as strong. We are here to dissolve some of the myths and help educate both our customers and anyone looking to learn more regarding Propylene Glycol & Vegetable Glycerin.


Propylene Glycol

Propylene Glycol (PG) is an organic compound that is produced from Propylene Oxide, it has a molecular formula of CH3CHCH2O. Now, before anyone throws a red flag, we’d like to point out that everything is a chemical. CBD is a chemical, water is a chemical, everything, whether natural or made in a lab, is a chemical. Food grade Propylene Glycol is recognized as safe by the US Food and Drug Administration. Interesting fact: PG is used in hospitals to help clean out build up in patient’s lungs, in vapor form. Its main applications are for food, pharmaceutical products, and of course, e-juice.


Vegetable Glycerin

Vegetable Glycerin (VG) is exactly what it implies, a form of vegetable oil. It's generally extracted from plant oils such as soy, coconut, or palm. It is clear, odorless, and typically sweet to taste. It’s highly viscous and very thick, similar to most CBD tinctures on the market today. The main uses for VG are: cosmetic products, food production, and e-juice. This also is considered safe by the US Food and Drug Administration.


Why use PG/VG?

Standard Practice is to mix the two liquids to get the desired result you want from your vape. Misthub has done a wonderful job outlining this practice in the graphic below.

Image Source: https://www.misthub.com/blogs/vape-tutorials/76788613-tutorial-propylene-glycol-pg-vs-vegetable-glycerin-vg-e-juice

By using a heavily concentrated CBD Isolate, it gives us a lot of variance in how we want to work with CBD and delivering it to the body. As stated earlier, vaping is far more efficient than ingestion from absorption and bioavailability to the speed at which you feel it’s effects. What if we told you it’s actually safer too? Because of the temperature for vaporization is much higher without burn off for these liquids, it can be heated at a much lower temperature reducing the negative effects from vaping CBD in its broad spectrum or full spectrum form. In other words, it heats up a lot cleaner than plant terpenes do from the Hemp plant. At Zen Alchemy Labs, we want to utilize the art of vapor to intake CBD, with a cleaner approach to our holistic plant friend, Hemp.


So, is it safe?

Yes. Our lab results from Third-Party testing shows 140mg/ml of CBD Isolate in our vape pod formula. Each pod holds approximately .7ml of e-liquid and 100mg/ml of CBD Isolate. Our CBD Isolate is sourced from organically grown hemp in Oregon. The PG/VG is food grade and the added flavoring is all natural with Third-Party testing as well.


COTTON PODS VS CERAMIC PODS

At Zen Alchemy Labs, we chose cotton pods for a variety of reasons. Although, it has become quite popular in the CBD community that ceramic is the best option, we’re not sure this necessarily true. In comparison, both cotton and ceramic pods will work in the method of combustion. Ceramic is better for regulating temperatures and preventing what’s known in the vape community as “dry burn”.

However, ceramic coils have been known to release dangerous chemicals when heated. This is problematic for us from a company standpoint and we don’t want to run that risk on our customers. The cotton pods also allow larger hits, with a more flavorful output. Because of this we decided to go with cotton pods, which cost more than ceramic pods. The hemp community has a very big advocacy for ceramic, but there are too many disadvantages and safety concerns to merit the cheaper cost. Here is a link describing the advantages and disadvantages of ceramic coils, supporting the decisions we made.


Source: https://www.vapingpost.com/2016/10/04/ceramic-coils-advantages-and-disadvantages/




Tl:DR (too long:didn’t read)

Our goal at Zen Alchemy Labs is to provide you with the purest quality CBD Products backed by Science, to enhance your life through physical and mental regeneration.

By using our organically grown hemp derived CBD Isolate, we can ensure passing of a drug test, while providing 90% of the effects given from a Full Spectrum or Broad-Spectrum blend. It is less likely to cause potential unexpected allergic reactions, and is a safer way to experiment with CBD when all the other variables have been removed. It’s nice to have the security of knowing exactly what is being put in your body at a given time. Choosing our CBD products is more economical, allowing us to provide healing benefits to even the average person, who can’t afford to regularly invest in higher amounts to get the relief they need. We have all variants available, depending on your needs. From using the flower fresh from the farm, to its isolated state we can provide you with the solution you want, based off your needs.


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